Molecular biomarker techniques serve as valuable adjuncts to urine cytology and bladder cystoscopy in diagnosing urothelial carcinomas due to their limitations. The FDA-cleared oncoFISH bladder application offers a solution by scanning and analyzing cells from a voided urine sample fixed on a microscope slide.

Utilizing a panel of four FISH probes, it targets specific chromosomal regions associated with urothelial carcinomas. The Ikoniscope robotic microscope conducts three-dimensional imaging and analysis of cells and their FISH signals to detect aneuploidy or chromosomal deletions.

This automated process ensures quick scanning with high-quality images, reducing the limitations of manual analysis such as low throughput and fluorescence bleaching. Results, including cell images and tabulated data, are presented for review and reporting, streamlining the diagnostic process.

oncoFISH PTEN is an automated microscopy application designed for the FISH-based detection of PTEN gene deletions in prostate tissue biopsies. Prostate cancer, the most common cancer in men, poses significant health risks, with a notable association between PTEN gene deletions and more aggressive forms of the disease.

The integration of PTEN genetic information with routine histology offers valuable prognostic insights, aiding physicians in formulating tailored treatment plans for patients. The oncoFISH PTEN application allows precise scanning of tissue areas, referencing H&E or immunostained slides for analysis.

Utilizing high-resolution slide scanning, low magnification analysis identifies glandular tissue, followed by detailed analysis at higher magnification to determine PTEN deletion status in cells. This comprehensive approach enhances diagnostic accuracy and informs clinical decision-making in prostate cancer management.